منابع مشابه
TRAP builds a better translocon
In This Issue In This Issue TRAP builds a better translocon or over a decade, mechanistic studies of protein translocation into the mammalian ER have relied on proteoliposomes with translocons reconstituted from purified components, a system that efficiently translocates simple model proteins like prolactin, but often fails to match in vivo translo-cation efficiency for other substrates. On pag...
متن کاملBuilding a better Trap.
A wide variety of antiangiogenic agents are now being tested in late-stage cancer patients as stand-alone agents or in combination with standard therapy (1). Although there have been mixed reviews so far, a success story appears to be emerging (2). In a recently concluded Phase III clinical trial involving patients with advanced colon cancer, Avastin [antivascular endothelial growth factor (VEG...
متن کاملBuilding a better virus trap.
The concept of ecological 'traps' is based in theory from ecology and conservation biology that has now found application to infectious diseases with a study from Paul Turner's group. This study is important because it offers a mathematical model of ecological traps, applies this model to viruses, and tests the model in a bacteria-phage system. Although there will be technical hurdles to overco...
متن کاملOwatonna (Minnesota) Builds a Library
Although Owatonna, Minnesota, enjoyed a limited amount of social library provision from the mid-nineteenth century onward, it was not until the 1890s that pressure mounted for a public library to be established under the terms of the State Library Act of 1879. The opportunity to provide a public library arose with a bequest from Mr. and Mrs. Elisha Hunewill, who had run a hardware business in t...
متن کاملHow a plant builds leaves.
A leaf develops from a few cells that grow, divide, and differentiate to form a complex organ that is precisely positioned relative to its neighbors. How cells communicate to achieve such coordinated growth and development is the focus of this review. We discuss (1) how the stem cells within the shoot meristem gain competence to form organs, (2) what determines the positioning and initiation of...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2003
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb1604iti2